On-Demand Webinar: High-Throughput Process & Analytical Platforms to Accelerate Gene Therapy Scale-Up

For revolutionary gene therapies to reach their full therapeutic potential, high throughput process development workflows are needed to keep pace with the ever-changing landscape of capsids and payloads. In addition, many of the current analytical testing methods are either not able to match the pace of process development, use too much material, or are inherently unsuited to support various unit-operations. As a result, they become a bottleneck to these essential therapies reaching the clinic in a timely manner. 

While we continue to discover the broad applications of the various AAV serotypes, their distinct biological properties require tailored, stage-appropriate analytical methods. These methods must be able to provide higher resolution, while also using less material or providing novel insights to keep pace with the ever-increasing speed of process development activities. 

In this webinar, hear from Patrick Starremans, Ph.D., Director of Analytical Development for the Gene Therapy franchise at Resilience, Nithya Jesuraj, Ph.D., Senior Manager of Commercial Development for the Gene Therapy franchise at Resilience, and Kenneth Warrington, Ph.D., Chief Technology Officer of Lacerta Therapeutics.  

WHAT YOU WILL LEARN IN THIS WEBINAR: 

• 1. How serotype agnostic analytics for AAV manufacturing will help reduce testing costs 
• 2. Why current methods to scale-up to larger bioreactors are not sustainable due to cost, transfection efficiency, and physical properties 
• 3. Why using an advanced platform with a reduced number of plasmids may increase vector titer by 1-2 logs, resulting in a significantly lower cost of goods sold (COGS) 
• 4. How Resilience & Lacerta are solving the current challenges and innovating to meet patient demand & reduce overall COGS 
  
  

MOMENTS OF INTEREST

• 0:00-2:18: Introduction 
• 2:18- 11:55: Resilience Overview, Gene Therapy Network & Capabilities – Nithya Jesuraj 
  12:57-20:55: Resilience’s Modular Platform Approach – Patrick Starremans 
  20:57-24:44: High Throughput Approach to Process Development - Patrick Starremans 
  24:45-31:05: Examples of Advanced Analytics at Resilience - Patrick Starremans 
  33:43-46:49: OneBac AAV Manufacturing Platform – Kenneth Warrington 
  46:57-48:10: Gene Therapy Network and Conclusion 
  48:18-58:55: Live Q&A