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On-demand Video: Efficiency Meets Economy: The Power of Single-Use Chromatography in mAb Purification



  • The current large-scale manufacturing of monoclonal antibodies (mAbs) using conventional packed-bed column technology presents a challenge in the development of an efficient and economical downstream purification process. Conventional packed-bed capture chromatography presents a bottleneck due to low productivity and physical characteristics. An efficient and economical capture chromatography is needed to develop sustainable protein purification processes.
  • Over the last two decades, technological progress in Protein A membrane chemistry has contributed to the advancement of novel and more affordable bio-separation devices with high binding capacities and improved mass transfer properties. We are testing Protein A membrane chromatography technology to develop efficient purification processes for our clients.
  • Our findings from a recent case study showcased that single-use chromatographic clarification technology can increase productivity by six times at the capture step in mAb purification. These results demonstrated market competitive capabilities of Protein A membrane technology for the commercial purification of mAb products.

This presentation was originally delivered at the 15th Annual Bioprocessing Summit on Aug 15, 2023. 

Ugur Gulmen presentation at BioProcessing Summit-THUMBNAIL2
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